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Robust W/O/W Emulsion Stabilized by Genipin-Cross-Linked Sugar Beet Pectin-Bovine Serum Albumin Nanoparticles: Co-encapsulation of Betanin and Curcumin.
- Source :
-
Journal of agricultural and food chemistry [J Agric Food Chem] 2021 Feb 03; Vol. 69 (4), pp. 1318-1328. Date of Electronic Publication: 2021 Jan 22. - Publication Year :
- 2021
-
Abstract
- Betanin and curcumin hold promise as natural colorants and antioxidants for food purposes due to their anti-hypertensive, anti-inflammation, and anti-tumor effects. However, the thermal stability and bioavailability of betanin and curcumin still need improvement. Here, we fabricated sugar beet pectin-bovine serum albumin nanoparticles (SBNPs) with a mean particle size of 180 ± 5.2 nm through a genipin cross-linking strategy to stabilize a type of Pickering water-in-oil-in-water (W/O/W) emulsion and co-encapsulated betanin and curcumin. First, the W <subscript>1</subscript> /O emulsion was homogenized with gelatin (the gelling agent) in the water phase and polyglycerol polyricinoleate (a lipophilic surfactant) in the oil phase. Later, W <subscript>1</subscript> /O was homogenized with another water phase containing SBNPs. The microstructure of the emulsion was regulated by the particle concentration ( c ) and W <subscript>1</subscript> /O volume fraction (Φ), especially the gel-like high internal phase emulsions were formed at the Φ up to 70%. In this case, betanin was encapsulated in the internal water phase (encapsulation efficiency = 65.3%), whereas curcumin was in the medium-chain triglyceride (encapsulation efficiency = 84.1%). Meanwhile, the shelf stability of betanin and curcumin was improved. Furthermore, the stability of bioactive compounds was potentiated by an emulsion gel in simulated gastrointestinal digestion, resulting in higher bioaccessibility. The aforementioned results suggest that SBNP-stabilized Pickering W/O/W emulsions could be a potential alternative to co-encapsulate betanin and curcumin with enhancement of shelf stability and bioaccessibility.
- Subjects :
- Animals
Betacyanins pharmacology
Biological Availability
Cattle
Cell Survival drug effects
Curcumin pharmacology
Digestion
Drug Compounding
Emulsions chemistry
Humans
Nanoparticles chemistry
Particle Size
Beta vulgaris chemistry
Betacyanins chemistry
Curcumin chemistry
Pectins chemistry
Plant Extracts chemistry
Serum Albumin, Bovine chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1520-5118
- Volume :
- 69
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of agricultural and food chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 33480679
- Full Text :
- https://doi.org/10.1021/acs.jafc.0c05212