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Novel insights into macrophage diversity in rheumatoid arthritis synovium.
- Source :
-
Autoimmunity reviews [Autoimmun Rev] 2021 Mar; Vol. 20 (3), pp. 102758. Date of Electronic Publication: 2021 Jan 18. - Publication Year :
- 2021
-
Abstract
- Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease affecting joints and causing progressive damage and disability. Macrophages are of critical importance in the initiation and perpetuation of synovitis in RA, they can function as antigen presenting cells leading to T-cell dependent B-cell activation, assume a variety of inflammatory cell states with the production of destructive cytokines, but also contribute to tissue homeostasis/repair. The recent development of high-throughput technologies, including bulk and single cells RNA-sequencing, has broadened our understanding of synovial cell diversity, and opened novel perspectives to the discovery of new potential therapeutic targets in RA. In this review, we will focus on the relationship between the synovial macrophage infiltration and clinical disease severity and response to treatment. We will then provide a state-of-the-art picture of the biological roles of synovial macrophages and distinct macrophage subsets described in RA. Finally, we will review the effects of approved conventional and biologic drugs on the synovial macrophage component and highlight the therapeutic potential of future strategies to re-program macrophage phenotypes in RA.<br /> (Copyright © 2021 Elsevier B.V. All rights reserved.)
- Subjects :
- Humans
Macrophages
Synovial Membrane
T-Lymphocytes
Arthritis, Rheumatoid
Synovitis
Subjects
Details
- Language :
- English
- ISSN :
- 1873-0183
- Volume :
- 20
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Autoimmunity reviews
- Publication Type :
- Academic Journal
- Accession number :
- 33476818
- Full Text :
- https://doi.org/10.1016/j.autrev.2021.102758