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Economical and easily detectable markers of digestive tumors: platelet parameters.

Authors :
Chen Y
Yang W
Ye L
Lin S
Shu K
Yang X
Ai X
Yao Y
Jiang M
Source :
Biomarkers in medicine [Biomark Med] 2021 Feb; Vol. 15 (3), pp. 157-166. Date of Electronic Publication: 2021 Jan 21.
Publication Year :
2021

Abstract

Aim: This study aimed to evaluate the clinical values of platelet parameters in patients with digestive tumors. Patients & methods: A total of 974 people were classified into three groups: malignant group, patients with digestive malignant tumors; benign group, patients with benign tumors; and normal group: healthy individuals. Results: Compared with the benign and normal groups, the malignant group showed significantly increased platelet count (PLT) and plateletcrit (PCT) and significantly reduced mean platelet volume (MPV) and platelet-large cell rate (P-LCR, p < 0.001). Elevated PLT and PCT and reduced MPV and P-LCR indicated poor overall survival in patients with digestive tumors. Conclusion: PLT, PCT, MPV and P-LCR were proven to be predictive biomarkers for patients with digestive malignant tumors. Elevated PLT and PCT or decreased MPV and P-LCR indicated poor overall survival.

Details

Language :
English
ISSN :
1752-0371
Volume :
15
Issue :
3
Database :
MEDLINE
Journal :
Biomarkers in medicine
Publication Type :
Academic Journal
Accession number :
33474972
Full Text :
https://doi.org/10.2217/bmm-2020-0203