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Clinical pregnancy is significantly associated with the blastocyst width and area: a time-lapse study.
- Source :
-
Journal of assisted reproduction and genetics [J Assist Reprod Genet] 2021 Apr; Vol. 38 (4), pp. 847-855. Date of Electronic Publication: 2021 Jan 20. - Publication Year :
- 2021
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Abstract
- In order to maintain pregnancy rates following single embryo transfer, optimisation of embryo culture and selection is vital. Time-lapse monitoring (TLM) has the potential to play a crucial role by providing sequential images of embryo development and minimal disturbance. Therefore, in this study morphometric assessment of blastocyst area and maximum width was performed in order to evaluate if these parameters are associated with pregnancy outcomes in IVF/ICSI cycles. This is a retrospective study of 664 patients who had elective single blastocyst transfer (eSBT). The EmbryoScope drawing tools were used to measure specific variables such as the maximum blastocyst width and blastocyst area. Our results show that women who were pregnant had significantly (P < 0.01) larger blastocyst width [median (range) μm] 184 (125-239) versus non-pregnant, 160 (120-230)] and area [median (range) μm <superscript>2</superscript> ] 26099 (12101-45,280) versus non-pregnant women, 22,251 (10992-37,931)]. A univariate logistic regression performed showed that blastocyst width [(OR = 1.026, 95% CI = (1.019, 1.033)] was significant (P < 0.01) and for every μm increase of blastocyst width, the odds of clinical pregnancy increase by 2.6%. A univariate logistic regression performed showed that blastocyst area [(OR = 1.00008, 95% CI = (1.00006, 1.00011)] was significant with P < 0.01. For every μm <superscript>2</superscript> increase of blastocyst area, our data showed the odds of clinical pregnancy increase by 0.008%. Hosmer-Lemeshow tests of calibrations were performed to verify calibration. Although our findings show a clear correlation between blastocyst dimensions and the clinical pregnancy rate, further studies are necessary to confirm these observations.
- Subjects :
- Adult
Blastocyst metabolism
Embryo Implantation physiology
Embryo Transfer
Female
Fertilization in Vitro
Humans
Live Birth epidemiology
Live Birth genetics
Pregnancy
Pregnancy Outcome
Pregnancy Rate
Single Embryo Transfer
Time-Lapse Imaging
Blastocyst cytology
Embryo Culture Techniques
Embryo Implantation genetics
Embryonic Development genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1573-7330
- Volume :
- 38
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of assisted reproduction and genetics
- Publication Type :
- Academic Journal
- Accession number :
- 33471232
- Full Text :
- https://doi.org/10.1007/s10815-021-02071-x