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Mass spectrometry reveals potential of β-lactams as SARS-CoV-2 M pro inhibitors.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2021 Feb 15; Vol. 57 (12), pp. 1430-1433. - Publication Year :
- 2021
-
Abstract
- The main viral protease (Mpro) of SARS-CoV-2 is a nucleophilic cysteine hydrolase and a current target for anti-viral chemotherapy. We describe a high-throughput solid phase extraction coupled to mass spectrometry Mpro assay. The results reveal some β-lactams, including penicillin esters, are active site reacting Mpro inhibitors, thus highlighting the potential of acylating agents for Mpro inhibition.
- Subjects :
- Acylation
Antiviral Agents chemistry
COVID-19 virology
Catalytic Domain
High-Throughput Screening Assays
Humans
Molecular Docking Simulation
Molecular Dynamics Simulation
Protease Inhibitors chemistry
SARS-CoV-2 enzymology
beta-Lactams chemistry
Antiviral Agents pharmacology
Cysteine Endopeptidases drug effects
Mass Spectrometry methods
Protease Inhibitors pharmacology
SARS-CoV-2 drug effects
beta-Lactams pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 57
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 33462575
- Full Text :
- https://doi.org/10.1039/d0cc06870e