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State-dependent responses to intracranial brain stimulation in a patient with depression.
- Source :
-
Nature medicine [Nat Med] 2021 Feb; Vol. 27 (2), pp. 229-231. Date of Electronic Publication: 2021 Jan 18. - Publication Year :
- 2021
-
Abstract
- Deep brain stimulation is a promising treatment for severe depression, but lack of efficacy in randomized trials raises questions regarding anatomical targeting. We implanted multi-site intracranial electrodes in a severely depressed patient and systematically assessed the acute response to focal electrical neuromodulation. We found an elaborate repertoire of distinctive emotional responses that were rapid in onset, reproducible, and context and state dependent. Results provide proof of concept for personalized, circuit-specific medicine in psychiatry.
- Subjects :
- Adult
Brain diagnostic imaging
Brain physiopathology
Brain Mapping
Deep Brain Stimulation methods
Depressive Disorder, Major diagnostic imaging
Depressive Disorder, Major physiopathology
Electric Stimulation methods
Electrodes
Female
Humans
Brain ultrastructure
Deep Brain Stimulation adverse effects
Depressive Disorder, Major therapy
Electric Stimulation adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1546-170X
- Volume :
- 27
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Nature medicine
- Publication Type :
- Academic Journal
- Accession number :
- 33462446
- Full Text :
- https://doi.org/10.1038/s41591-020-01175-8