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Immunotherapy with NK cells: recent developments in gene modification open up new avenues.
- Source :
-
Oncoimmunology [Oncoimmunology] 2020 Sep 02; Vol. 9 (1), pp. 1777651. Date of Electronic Publication: 2020 Sep 02. - Publication Year :
- 2020
-
Abstract
- Chimeric antigen receptor (CAR)-T cell therapies have achieved remarkable success. However, application-related toxicities, such as cytokine release syndrome or neurotoxicity, moved natural killer (NK) cells into focus as novel players in immunotherapy. CAR-NK cells provide an advantageous dual killing-capacity by CAR-dependent and -independent mechanisms and induce few side effects. While the majority of trials still use CAR-T cells, CAR-NK cell trials are on the rise with 19 ongoing studies worldwide. This review illuminates the current state of research and clinical application of CAR-NK cells, as well as future developmental potential.<br /> (© 2020 The Author(s). Published with license by Taylor & Francis Group, LLC.)
Details
- Language :
- English
- ISSN :
- 2162-402X
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Oncoimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 33457093
- Full Text :
- https://doi.org/10.1080/2162402X.2020.1777651