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A pilot study: Relationship between Bisphenol A, Bisphenol A glucuronide and sex steroid hormone levels in cord blood in A South African population.
- Source :
-
Reproductive toxicology (Elmsford, N.Y.) [Reprod Toxicol] 2021 Mar; Vol. 100, pp. 83-89. Date of Electronic Publication: 2021 Jan 13. - Publication Year :
- 2021
-
Abstract
- Exposure to Bisphenol A (BPA) during early development particularly in- utero has been linked to a wide range of pathology. The aim of this study was to examine the relationship of BPA and its naturally occurring metabolite BPA-glucuronide (BPA-g) with sex steroid hormone levels in South African mother-child pairs. Third-trimester serum maternal samples and matching cord blood samples were analyzed for BPA, BPA-g and nine sex steroid hormones using liquid chromatography tandem mass spectrometry (LC-MS/MS). Sixty maternal and child pairs were analyzed. Rank correlation demonstrated a significant positive relationship between cord blood estradiol and cord blood BPA (p = 0.002) and maternal BPA levels (p = 0.02) respectively. Cord blood testosterone from male infants showed a negative Spearman's correlation (r=-0.5, p = 0.02) with maternal BPA-g. There was no statistical difference in total testosterone levels in cord blood from male and female infants. The findings of the current study indicate a significant relationship between some key sex steroid hormones namely testosterone, dihydrotestosterone and estradiol and fetal exposure BPA.<br /> (Copyright © 2021. Published by Elsevier Inc.)
- Subjects :
- Adolescent
Adult
Dihydrotestosterone blood
Endocrine Disruptors blood
Estradiol blood
Female
Humans
Infant, Newborn
Male
Pilot Projects
Pregnancy
Pregnancy Trimester, Third
South Africa
Testosterone blood
Young Adult
Benzhydryl Compounds blood
Fetal Blood chemistry
Glucuronides blood
Gonadal Steroid Hormones blood
Phenols blood
Subjects
Details
- Language :
- English
- ISSN :
- 1873-1708
- Volume :
- 100
- Database :
- MEDLINE
- Journal :
- Reproductive toxicology (Elmsford, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 33453334
- Full Text :
- https://doi.org/10.1016/j.reprotox.2021.01.004