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Gabapentin Relieves Vertigo of Periodic Vestibulocerebellar Ataxia: 3 Cases and Possible Mechanism.
- Source :
-
Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2021 May; Vol. 36 (5), pp. 1264-1267. Date of Electronic Publication: 2021 Jan 16. - Publication Year :
- 2021
-
Abstract
- Objective: The aim of this study was to report relief of optokinetic-triggered vertigo (OKTV) with low-dose gabapentin in three patients with periodic vestibulocerebellar ataxia [episodic ataxia type 4 (EA4); OMIM 606552].<br />Methods: Clinical observations and analysis of video-recorded eye movements were used before and after gabapentin.<br />Results: Gabapentin relieved vertigo of all three treated patients with EA4, particularly during activities that typically would induce vertiginous symptoms. Two patients reported 8-12 hours of sustained relief after the first 100 mg dose. One has benefited from 100-200 mg TID for 7 years. Video analysis of nystagmus revealed improved target tracking on smooth pursuit and a steadier gaze hold.<br />Conclusions: Gabapentin effectively relieved the optokinetic-triggered vertigo in our patients with EA4. Mechanisms are postulated in terms of known tight gabapentin binding to the Purkinje cell voltage-gated calcium channel. The observations may offer insight into this rare disease's neuropathology. © 2021 International Parkinson and Movement Disorder Society.<br /> (© 2021 International Parkinson and Movement Disorder Society.)
Details
- Language :
- English
- ISSN :
- 1531-8257
- Volume :
- 36
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Movement disorders : official journal of the Movement Disorder Society
- Publication Type :
- Academic Journal
- Accession number :
- 33452831
- Full Text :
- https://doi.org/10.1002/mds.28491