Identification of placental androgen receptor isoforms in a sheep model of maternal allergic asthma.

Authors :: Meakin AS
Morrison JL
Bradshaw EL
Holman SL
Saif Z
Gatford KL
Wallace MJ
Bischof RJ
Moss TJM
Clifton VL
Source :: Placenta [Placenta] 2021 Jan 15; Vol. 104, pp. 232-235. Date of Electronic Publication: 2021 Jan 06.
Publication Year :: 2021
Abstract: Maternal asthma is known to impact intrauterine growth outcomes, which may be mediated, in part, by altered androgen signalling. Our aim was to explore whether the sheep placenta expresses androgen receptor (AR) isoforms and determine if the differential expression of AR protein isoforms is altered by maternal asthma. Four known AR isoforms were detected (AR-FL, AR-v1, AR-v7, and AR-45), and their expression and subcellular distribution was altered in the presence of maternal allergic asthma. These findings underscore the importance for in vivo models of maternal asthma to delineate molecular patterns that may contribute to feto-placental growth and development.<br /> (Crown Copyright © 2021. Published by Elsevier Ltd. All rights reserved.)

Subjects :: Animals
Asthma genetics
Disease Models, Animal
Female
Pregnancy
Protein Isoforms genetics
Receptors, Androgen genetics
Sheep
Asthma metabolism
Placenta metabolism
Protein Isoforms metabolism
Receptors, Androgen metabolism

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