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Naloxone-induced conditioned place aversion score and extinction period are higher in C57BL/6J morphine-dependent mice than in Swiss: Role of HPA axis.
- Source :
-
Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2021 Feb; Vol. 201, pp. 173106. Date of Electronic Publication: 2021 Jan 12. - Publication Year :
- 2021
-
Abstract
- Intense associative memories develop between drug-paired contextual cues and the drug withdrawal associated aversive feeling. They have been suggested to contribute to the high rate of relapse. Our study was aimed to elucidate the involvement of hypothalamic-pituitary-adrenocortical (HPA) axis activity in the expression and extinction of aversive memory in Swiss and C57BL/6J (B6) mice. The animals were rendered dependent on morphine by i.p. injection of increasing doses of morphine (10-60 mg/kg). The negative state associated with naloxone (1 mg/kg s.c.) precipitated morphine withdrawal was examined by using conditioned place aversion (CPA) paradigm. B6 mice obtained a higher aversion score and took longer to extinguish the aversive memory than Swiss mice. In addition, corticosterone levels were increased after CPA expression. Moreover, corticosterone levels were decreased during CPA extinction in Swiss mice without changes in B6 mice. Pre-treatment with the selective CRF1 receptor antagonist CP-154,526 before naloxone, impaired morphine-withdrawal aversive memory acquisition and decreased the extinction period. CP-154,526 also antagonized the increased levels of corticosterone observed after CPA expression in Swiss mice, without any changes in B6 mice. These results indicate that HPA axis could be a critical factor governing opioid withdrawal memory storage and retrieval, but in a strain or stock-specific manner. The differences observed between Swiss and B6 mice suggest that the treatment of addictive disorders should consider different individual predisposition to associate the aversive learning with the context.<br /> (Copyright © 2021 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Avoidance Learning drug effects
Male
Memory drug effects
Mice
Mice, Inbred C57BL
Morphine administration & dosage
Narcotics administration & dosage
Pyrimidines administration & dosage
Pyrroles administration & dosage
Receptors, Corticotropin-Releasing Hormone antagonists & inhibitors
Substance Withdrawal Syndrome psychology
Conditioning, Operant drug effects
Extinction, Psychological drug effects
Hypothalamo-Hypophyseal System drug effects
Morphine Dependence psychology
Naloxone administration & dosage
Narcotic Antagonists administration & dosage
Pituitary-Adrenal System drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1873-5177
- Volume :
- 201
- Database :
- MEDLINE
- Journal :
- Pharmacology, biochemistry, and behavior
- Publication Type :
- Academic Journal
- Accession number :
- 33444599
- Full Text :
- https://doi.org/10.1016/j.pbb.2021.173106