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Gramicidin A-based unimolecular channel: cancer cell-targeting behavior and ion transport-induced apoptosis.
- Source :
-
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2021 Feb 02; Vol. 57 (9), pp. 1097-1100. - Publication Year :
- 2021
-
Abstract
- A series of glycoside-peptide conjugates were prepared by engineering at the N-terminus of the natural peptide gramicidin A. The conjugate containing galactose moiety formed a unimolecular transmembrane channel and mediated ion transport to induce apoptosis of cancer cells. More importantly, it exhibited liver cancer cell-targeting behavior due to the galactose-asialoglycoprotein receptor recognition.
Details
- Language :
- English
- ISSN :
- 1364-548X
- Volume :
- 57
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Chemical communications (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 33443269
- Full Text :
- https://doi.org/10.1039/d0cc08073j