Back to Search
Start Over
Mitochondrial Dysfunction and Heart Disease: Critical Appraisal of an Overlooked Association.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2021 Jan 09; Vol. 22 (2). Date of Electronic Publication: 2021 Jan 09. - Publication Year :
- 2021
-
Abstract
- The myocardium is among the most energy-consuming tissues in the body, burning from 6 to 30 kg of ATP per day within the mitochondria, the so-called powerhouse of the cardiomyocyte. Although mitochondrial genetic disorders account for a small portion of cardiomyopathies, mitochondrial dysfunction is commonly involved in a broad spectrum of heart diseases, and it has been implicated in the development of heart failure via maladaptive circuits producing and perpetuating mitochondrial stress and energy starvation. In this bench-to-bedside review, we aimed to (i) describe the key functions of the mitochondria within the myocardium, including their role in ischemia/reperfusion injury and intracellular calcium homeostasis; (ii) examine the contribution of mitochondrial dysfunction to multiple cardiac disease phenotypes and their transition to heart failure; and (iii) discuss the rationale and current evidence for targeting mitochondrial function for the treatment of heart failure, including via sodium-glucose cotransporter 2 inhibitors.
- Subjects :
- Animals
Calcium metabolism
Cardiomyopathies metabolism
Cardiomyopathies pathology
Energy Metabolism
Heart Diseases metabolism
Heart Failure metabolism
Heart Failure pathology
Humans
Mitochondria, Heart metabolism
Mitochondrial Dynamics
Myocardial Reperfusion Injury metabolism
Myocardial Reperfusion Injury pathology
Heart Diseases pathology
Mitochondria, Heart pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 22
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 33435429
- Full Text :
- https://doi.org/10.3390/ijms22020614