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IDH-Mutant Astrocytoma With Chromosome 19q13 Deletion Manifesting as an Oligodendroglioma-Like Morphology.
- Source :
-
Journal of neuropathology and experimental neurology [J Neuropathol Exp Neurol] 2021 Feb 22; Vol. 80 (3), pp. 247-253. - Publication Year :
- 2021
-
Abstract
- Partial deletions in chromosomes 1p and 19q are found in a subset of astrocytic tumors; however, it remains unclear how these alterations affect their histological features and prognosis. Herein, we present 3 cases of isocitrate dehydrogenase (IDH)-mutant astrocytoma with chromosome 19q13 deletion. In the first case, the primary tumor harbored an IDH1 mutation with chromosome 1p/19q partial deletions, which covered 19q13 and exhibited a durable initial response to radiotherapy and temozolomide (TMZ) treatment. However, the tumor lost the chromosome 1p/19q partial deletions at recurrence and became resistant to TMZ. Histologically, an oligodendroglioma-like feature was found in the primary tumor but not in the recurrent tumor. Capicua transcriptional repressor (CIC), located on 19q13, was less expressed in the primary tumor but was highly expressed in the recurrent tumor. Similar histological findings were observed in 2 other astrocytic tumors with IDH1 or IDH2 mutations. These tumors also had chromosome 19q13 deletion, including the CIC gene, weakly expressed CIC, and oligodendroglioma-like morphology. These tumors recurred at 6 and 32 months, respectively. These findings suggest that IDH-mutant astrocytoma with chromosome 19q13 partial deletion, including the CIC gene, may induce an oligodendroglioma-like phenotype, but the clinical prognosis may not be similar to that of genetically defined oligodendroglioma.<br /> (© 2021 American Association of Neuropathologists, Inc. All rights reserved.)
- Subjects :
- Adult
Animals
Astrocytoma diagnostic imaging
Brain Neoplasms diagnostic imaging
Female
Humans
Male
Mice
Mice, SCID
Mutation genetics
Oligodendroglioma diagnostic imaging
Astrocytoma genetics
Brain Neoplasms genetics
Chromosome Deletion
Chromosomes, Human, Pair 19 genetics
Isocitrate Dehydrogenase genetics
Oligodendroglioma genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1554-6578
- Volume :
- 80
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of neuropathology and experimental neurology
- Publication Type :
- Academic Journal
- Accession number :
- 33432322
- Full Text :
- https://doi.org/10.1093/jnen/nlaa161