Case Report and Genomic Characterization of a Novel Porcine Nodavirus in the United States.

Nodaviruses are small bisegmented RNA viruses belonging to the family Nodaviridae . Nodaviruses have been identified in different hosts, including insects, fishes, shrimps, prawns, dogs, and bats. A novel porcine nodavirus was first identified in the United States by applying next-generation sequencing on brain tissues of pigs with neurological signs, including uncontrollable shaking. RNA1 of the porcine nodavirus had the highest nucleotide identity (51.1%) to the Flock House virus, whereas its RNA2 shared the highest nucleotide identity (48%) with the RNA2 segment of caninovirus (Canine nodavirus). Genetic characterization classified porcine nodavirus as a new species under the genus Alphanodavirus . Further studies are needed to understand the pathogenicity and clinical impacts of this virus.