Back to Search Start Over

Association of methotrexate use and lymphoproliferative disorder in patients with rheumatoid arthritis: Results from a Japanese multi-institutional retrospective study.

Authors :
Honda S
Sakai R
Inoue E
Majima M
Konda N
Takada H
Kihara M
Yajima N
Nanki T
Yamamoto K
Takeuchi T
Harigai M
Source :
Modern rheumatology [Mod Rheumatol] 2022 Jan 05; Vol. 32 (1), pp. 16-23.
Publication Year :
2022

Abstract

Objectives: To investigate the risk factors and clinical characteristics of lymphoproliferative disorder (LPD) in Japanese patients with rheumatoid arthritis (RA).<br />Methods: We enrolled patients with RA aged ≥20 years who visited the participating hospitals between April 2011 and July 2011. We investigated the risk factors for LPD using a Cox proportional hazard model and described pathological features and vital prognosis of LPD in patients with RA.<br />Results: We enrolled 9815 patients with the following characteristics at baseline: female 79.4%, median age 63 years; median disease duration 7 years; median DAS28-CRP (3) 3.1; prevalence of MTX use 60.0%. Sixty-eight patients (0.69%) developed LPD in 3-year observation period. Multivariable analysis showed that age by decade (hazard ratio [95% confidence interval], 1.47 [1.18-1.85]) and MTX use at baseline (2.35 [1.25-4.42] for ≤8 mg/week, 4.39 [2.07-9.32] for >8 mg/week versus non-use) were significant risk factors of LPD. Of 55 patients with pathological diagnosis, diffuse large B cell lymphoma was the most frequent (54%). The 5-year mortality of LPD was 24%. The major cause of death was lymphoma (81%).<br />Conclusion: This nationwide study revealed risk factors, clinical characteristics, and prognosis of LPD in the largest number of Japanese patients with RA.<br /> (© 2021 Japan College of Rheumatology.)

Details

Language :
English
ISSN :
1439-7609
Volume :
32
Issue :
1
Database :
MEDLINE
Journal :
Modern rheumatology
Publication Type :
Academic Journal
Accession number :
33428479
Full Text :
https://doi.org/10.1080/14397595.2020.1869370