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Evaluation of systemic involvement of Coronavirus disease 2019 through spleen; size and texture analysis
- Source :
-
Turkish journal of medical sciences [Turk J Med Sci] 2021 Jun 28; Vol. 51 (3), pp. 972-980. Date of Electronic Publication: 2021 Jun 28. - Publication Year :
- 2021
-
Abstract
- Background/aim: To investigate the changes in the spleen size, parenchymal heterogeneity, and computed tomography (CT) texture analysis features of patients diagnosed with Coronavirus disease 2019 (COVID-19)<br />Materials and Methods: The size and parenchymal structure of the spleen in 91 patients who underwent thoracic CT examination due to COVID-19 were evaluated. For the evaluation of parenchymal heterogeneity, CT texture analysis was performed using dedicated software (Olea Medical, France). The texture analysis of each case consisted of 15 first-order intensity-based features, 17 gray level co- occurrence matrix-based features, and 9 gray level run length matrix-based features.<br />Results: A total of 91 patients (45 males, 46 females) with a mean age of 54.31 ± 16.33 years (range: 18–81) were included in the study. A statistically significant decrease in spleen size was seen in the follow-up CT examinations (p < 0.001) whereas no statistically significant difference was found between the Hounsfield unit (HU) values. The radiomics consisted of first-order intensity-based features such as 90th percentile, maximum, interquartile range, range, mean absolute deviation, standard deviation, and variance, all of which showed statistically significant differences (p-values: < 0.001, < 0.001, 0.001, 0.003, 0.001, 0.001, and 0.004, respectively). “Correlation” as a gray level co-occurrence matrix-based feature and “gray level nonuniformity” as a gray level run length matrix-based feature showed statistically differences (p-values: 0.033 and < 0.001, respectively).<br />Conclusions: Although COVID-19 manifests with lung involvement in the early stage, it can also cause systemic involvement, and the spleen may be one of its target organs. A decrease in the spleen size and parenchymal microstructure changes can be observed in the short follow-up time. It is hoped that the changes in the parenchymal microstructure will be demonstrated by a noninvasive method: texture analysis.<br />Competing Interests: The author declare that they have no conflict of interest<br /> (This work is licensed under a Creative Commons Attribution 4.0 International License.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
COVID-19 epidemiology
Comorbidity
Female
Follow-Up Studies
Humans
Male
Middle Aged
Pandemics
Retrospective Studies
Splenic Diseases diagnosis
Turkey epidemiology
Young Adult
COVID-19 diagnosis
SARS-CoV-2
Spleen diagnostic imaging
Splenic Diseases epidemiology
Tomography, X-Ray Computed methods
Subjects
Details
- Language :
- English
- ISSN :
- 1303-6165
- Volume :
- 51
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Turkish journal of medical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 33421971
- Full Text :
- https://doi.org/10.3906/sag-2009-270