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Use of Untargeted Metabolomics to Explore the Air Pollution-Related Disease Continuum.
- Source :
-
Current environmental health reports [Curr Environ Health Rep] 2021 Mar; Vol. 8 (1), pp. 7-22. Date of Electronic Publication: 2021 Jan 09. - Publication Year :
- 2021
-
Abstract
- Purpose of Review: The purpose of this review is to summarize the application of untargeted metabolomics to identify the perturbation of metabolites or metabolic pathways associated with air pollutant exposures.<br />Recent Findings: Twenty-three studies were included in this review, in adults, children, or pregnant women. The most commonly measured air pollutant is particulate matter smaller than 2.5 μm. Size-fractioned particles, particle chemical species, gas pollutants, or organic compounds were also investigated. The reviewed studies used a wide range of air pollution measurement techniques and metabolomics analyses. Identified metabolites were primarily related to oxidative stress and inflammatory responses, and a few were related to the alterations of steroid metabolic pathways. The observed metabolic perturbations can differ by disease status, sex, and age. Air pollution-related metabolic changes were also associated with health outcomes in some studies. Our review shows that air pollutant exposures are associated with metabolic pathways primarily related to oxidative stress, inflammation, as assessed through untargeted metabolomics in 23 studies. More metabolomic studies with larger sample sizes are needed to identify air pollution components most responsible for adverse health effects, elaborate on mechanisms for subpopulation susceptibility, and link air pollution exposure to specific adverse health effects.
- Subjects :
- Adult
Child
Environmental Exposure adverse effects
Environmental Exposure analysis
Female
Humans
Metabolomics
Oxidative Stress
Particulate Matter adverse effects
Particulate Matter analysis
Pregnancy
Air Pollutants adverse effects
Air Pollutants analysis
Air Pollution adverse effects
Air Pollution analysis
Subjects
Details
- Language :
- English
- ISSN :
- 2196-5412
- Volume :
- 8
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Current environmental health reports
- Publication Type :
- Academic Journal
- Accession number :
- 33420964
- Full Text :
- https://doi.org/10.1007/s40572-020-00298-x