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Associations between continuous glucose monitoring-derived metrics and arterial stiffness in Japanese patients with type 2 diabetes.

Authors :
Wakasugi S
Mita T
Katakami N
Okada Y
Yoshii H
Osonoi T
Kuribayashi N
Taneda Y
Kojima Y
Gosho M
Shimomura I
Watada H
Source :
Cardiovascular diabetology [Cardiovasc Diabetol] 2021 Jan 07; Vol. 20 (1), pp. 15. Date of Electronic Publication: 2021 Jan 07.
Publication Year :
2021

Abstract

Background: Previous studies have suggested that high mean glucose levels and glycemic abnormalities such as glucose fluctuation and hypoglycemia accelerate the progression of atherosclerosis in patients with type 2 diabetes. Although continuous glucose monitoring (CGM) that could evaluate such glycemic abnormalities has been rapidly adopted, the associations between CGM-derived metrics and arterial stiffness are not entirely clear.<br />Methods: This exploratory cross-sectional study used baseline data from an ongoing prospective, multicenter, observational study with 5 years of follow-up. Study participants included 445 outpatients with type 2 diabetes and no history of apparent cardiovascular disease who underwent CGM and brachial-ankle pulse wave velocity (baPWV) measurement at baseline. Associations between CGM-derived metrics and baPWV were analyzed using multivariate regression models.<br />Results: In a linear regression model, all CGM-derived metrics were significantly associated with baPWV, but HbA1c was not. Some CGM-derived metrics related to intra-day glucose variability, hyperglycemia, and hypoglycemia remained significantly associated with baPWV after adjusting for possible atherosclerotic risk factors, including HbA1c. Based on baPWV ≥ 1800 cm/s as indicative of high arterial stiffness, multivariate logistic regression found that some CGM-derived metrics related to intra-day glucose variability and hyperglycemia are significantly associated with high arterial stiffness even after adjusting for possible atherosclerotic risk factors, including HbA1c.<br />Conclusions: Multiple CGM-derived metrics are significantly associated with baPWV and high arterial stiffness in patients with type 2 diabetes who have no history of apparent cardiovascular disease. These metrics might be useful for identifying patients at high risk of developing cardiovascular disease.

Details

Language :
English
ISSN :
1475-2840
Volume :
20
Issue :
1
Database :
MEDLINE
Journal :
Cardiovascular diabetology
Publication Type :
Academic Journal
Accession number :
33413339
Full Text :
https://doi.org/10.1186/s12933-020-01194-2