Rapid and label-free urine test based on surface-enhanced Raman spectroscopy for the non-invasive detection of colorectal cancer at different stages.

Authors :: Lin J
Huang Z
Lin X
Wu Q
Quan K
Cheng Y
Zheng M
Xu J
Dai Y
Qiu H
Lin D
Feng S
Source :: Biomedical optics express [Biomed Opt Express] 2020 Nov 11; Vol. 11 (12), pp. 7109-7119. Date of Electronic Publication: 2020 Nov 11 (Print Publication: 2020).
Publication Year :: 2020
Abstract: The concept of being able to urinate in a cup and screen for colorectal cancer (CRC) is fascinating to the public at large. Here, a simple and label-free urine test based on surface-enhanced Raman spectroscopy (SERS) was employed for CRC detection. Significant spectral differences among normal, stages I-II, and stages III-IV CRC urines were observed. Using discriminant function analysis, the diagnostic sensitivities of 95.8%, 80.9%, and 84.3% for classification of normal, stages I-II, and stages III-IV CRC were achieved in training model, indicating the great promise of urine SERS as a rapid, convenient and noninvasive method for CRC staging detection.<br />Competing Interests: The authors declare that there are no conflicts of interest related to this article.<br /> (© 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement.)

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