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Evaluation of antimicrobial photodynamic activities of 5-aminolevulinic acid derivatives.
- Source :
-
Photodermatology, photoimmunology & photomedicine [Photodermatol Photoimmunol Photomed] 2021 Jul; Vol. 37 (4), pp. 296-305. Date of Electronic Publication: 2021 Jan 21. - Publication Year :
- 2021
-
Abstract
- Background: Antibiotic resistance is increasing day by day, thereby increase the chances of more infections by resistant bacteria. In this situation, antimicrobial photodynamic therapy (aPDT) is gaining more attraction.<br />Objective: To evaluate the antimicrobial effect of ALA derivatives using photodynamic therapy.<br />Materials and Methods: In this study, we evaluated the aPDT effect of different derivatives of 5-ALA. In vivo and in vitro studies were performed to measure the antimicrobial activity. Different light doses and different concentrations of drugs were used to test anti-bacterial effect of drugs as well as to detect any physiological changes in animal model after the treatment.<br />Results: In vivo studies revealed that ALA-methyl ester, ALA-hexyl ester, and ALA-13A are potent photosensitizers. In vitro studies involved wound healing rate, body weight, and dietary intake were evaluated, and results showed that ALA, ALA-methyl ester, ALA-hexyl ester, and ALA-13A had good anti-bacterial effects, fast healing rate, and no effect on other physical parameters.<br />Conclusion: Photodynamic therapy is increasingly used to treat different types of skin infections caused by bacterial strains. Our studies revealed that ALA-methyl ester, ALA-hexyl ester, and ALA-13A are promising photosensitizers for photodynamic therapy to inhibit the growth of resistant bacterial strains.<br /> (© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Details
- Language :
- English
- ISSN :
- 1600-0781
- Volume :
- 37
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Photodermatology, photoimmunology & photomedicine
- Publication Type :
- Academic Journal
- Accession number :
- 33404073
- Full Text :
- https://doi.org/10.1111/phpp.12652