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A recombinant human collagen hydrogel for the treatment of partial-thickness burns: A prospective, self-controlled clinical study.
- Source :
-
Burns : journal of the International Society for Burn Injuries [Burns] 2021 May; Vol. 47 (3), pp. 634-642. Date of Electronic Publication: 2021 Jan 02. - Publication Year :
- 2021
-
Abstract
- Introduction: Allogeneic and xenogeneic skin are recognized as the best coverings for skin burn wounds, but currently face a supply shortage. To solve this problem, our research group developed a standardized manufactured hydrogel dressing based on a new type of highly bioactive recombinant human collagen.<br />Study Design: Prospective self-controlled trial.<br />Objective: To evaluate the efficacy and safety of recombinant human collagen hydrogel in the treatment of partial burn wounds to the skin compared to those of xenogeneic skin.<br />Methods: This study included twenty-one patients admitted to Shanghai Changhai Hospital within 48 h after receiving partial-thickness skin burns. The wounds were symmetrically separated along the axis and treated with recombinant human collagen hydrogel (RHCH) or a human-CTLA4-Ig gene-transferred pig skin xenotransplant. The condition of the wound surfaces was recorded on days 0 (of enrollment), 5, 10, 15, and 20, and bacterial drug sensitivity testing, hematuria examination, and electrocardiographic tests were conducted on days 0, 10, 20, or on the day of wound healing.<br />Results: There were no statistically significant differences in wound healing time between the two groups. The median number of days to healing was 11.00 ± 0.56 for xenogeneic skin vs. 11.00 ± 1.72 for RHCH.<br />Conclusion: During the observation period, the therapeutic effect of the RHCH developed by our group on partial-thickness burn wounds was not significantly different from that of gene-transferred xenogeneic skin. Thus, our designed RHCH shows potential for clinical use to treat burn wounds on the skin.<br /> (Copyright © 2020 Elsevier Ltd and ISBI. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1879-1409
- Volume :
- 47
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Burns : journal of the International Society for Burn Injuries
- Publication Type :
- Academic Journal
- Accession number :
- 33402311
- Full Text :
- https://doi.org/10.1016/j.burns.2020.01.006