Redox-sensitive nanoparticles based on xylan-lipoic acid conjugate for tumor targeted drug delivery of niclosamide in cancer therapy.

Authors :: Sauraj
Kumar A
Kumar B
Kulshreshtha A
Negi YS
Source :: Carbohydrate research [Carbohydr Res] 2021 Jan; Vol. 499, pp. 108222. Date of Electronic Publication: 2020 Dec 16.
Publication Year :: 2021
Abstract: In this study, novel redox-sensitive nanoparticles based on xylan-lipoic acid (Xyl-LA) conjugate were developed for tumor targeted delivery of niclosamide (Nic) in cancer therapy. The niclosamide loaded xylan-lipoic acid conjugate nanoparticles (Xyl-LA/Nic NPs) showed redox responsive behaviour in presence of reductive glutathione (GSH), which indicate their suitability for intracellular drug release. The obtained Xyl-LA/Nic NPs exhibited uniform particle size (196 ± 1.64 nm), high loading capacity (~28.6 wt %) and excellent blood compatibility. The anticancer activity of the Niclosamide and the Xyl-LA/Nic NPs against the colon carcinoma cell lines (HCT-15, Colo-320) were evaluated by MTT assay and the overall results indicate that the Xyl-LA/Nic NPs significantly enhanced the therapeutic efficiency of niclosamide in cancer therapy.<br /> (Copyright © 2020 Elsevier Ltd. All rights reserved.)

Subjects :: Antineoplastic Agents chemistry
Cell Line, Tumor
Cell Proliferation drug effects
Colonic Neoplasms pathology
Dose-Response Relationship, Drug
Drug Carriers chemistry
Drug Screening Assays, Antitumor
Humans
Molecular Structure
Niclosamide chemistry
Oxidation-Reduction
Particle Size
Antineoplastic Agents pharmacology
Colonic Neoplasms drug therapy
Drug Delivery Systems
Nanoparticles chemistry
Niclosamide pharmacology
Thioctic Acid chemistry
Xylans chemistry

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