Back to Search
Start Over
Polygala sabulosa A.W. Bennett extract mitigates motor and cognitive deficits in a mouse model of acute ischemia.
- Source :
-
Metabolic brain disease [Metab Brain Dis] 2021 Mar; Vol. 36 (3), pp. 453-462. Date of Electronic Publication: 2021 Jan 04. - Publication Year :
- 2021
-
Abstract
- Stroke is considered one of the leading causes of death worldwide. The treatment is limited; however, the Brazilian flora has a great source of natural products with therapeutic potentials. Studies with the medicinal plant Polygala sabulosa W. Bennett provided evidence for its use as an anti-inflammatory and neuroprotective drug. In the case of ischemic stroke due to lack of oxygen, both acute and chronic inflammatory processes are activated. Thus, we hypothesized that P. sabulosa (HEPs) has the potential to treat the motor and cognitive deficits generated by ischemic stroke. Male mice were subjected to global ischemia for 60 min, followed by reperfusion and orally treated with HEPs (100 mg/kg in saline + 3% tween 20) twice a day (12 h apart) for 48 h starting 3 h after surgery. Motor skills were assessed using grip force and open field tasks. Hippocampi were then collected for mRNA quantification of the cytokines IL-1-β and TNF-α levels. After 48 h of acute treatment, spatial reference memory was evaluated in a Morris water maze test for another group of animals. We show that HEPs treatment significantly prevented motor weakness induced by ischemia. Brain infarct area was reduced by 22.25% with downregulation of the levels of IL-1β and TNF-α mRNA. Learning performance and memory ability on Morris water maze task were similar to the sham group. Our data demonstrates the neuroprotective properties of HEPs through its anti-inflammatory activities, which prevent motor and cognitive impairments, suggesting that HEPs may be an effective therapy for ischemic stroke.
- Subjects :
- Animals
Brain Ischemia metabolism
Cognition drug effects
Cognitive Dysfunction metabolism
Disease Models, Animal
Hand Strength
Interleukin-1beta metabolism
Maze Learning drug effects
Mice
Motor Disorders metabolism
Motor Skills drug effects
Muscle Strength drug effects
Neuroprotective Agents pharmacology
Plant Extracts pharmacology
Tumor Necrosis Factor-alpha metabolism
Brain Ischemia drug therapy
Cognitive Dysfunction drug therapy
Motor Disorders drug therapy
Neuroprotective Agents therapeutic use
Plant Extracts therapeutic use
Polygala
Subjects
Details
- Language :
- English
- ISSN :
- 1573-7365
- Volume :
- 36
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Metabolic brain disease
- Publication Type :
- Academic Journal
- Accession number :
- 33394286
- Full Text :
- https://doi.org/10.1007/s11011-020-00660-w