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In Vitro and In Vivo Medicinal Value of Culinary-Medicinal Lung Oyster Mushroom Pleurotus pulmonarius var. stechangii (Agaricomycetes).
- Source :
-
International journal of medicinal mushrooms [Int J Med Mushrooms] 2020; Vol. 22 (8), pp. 763-774. - Publication Year :
- 2020
-
Abstract
- Pleurotus pulmonarius var. stechangii is a culinary-medicinal mushroom commonly cultivated in subtropical countries in Asia. In this study, the in vitro antixanthine oxidase, antihyperglycemic, and in vivo anti-inflammatory activities of a methanol extract (ME) of P. pulmonarius var. stechangii fruiting bodies were evaluated. The xanthine oxidase inhibitory activity of the ME of P. pulmonarius var. stechangii was lower than that of allopurinol, a xanthine oxidase inhibitor used as a positive control. Eleven phenolic compounds were identified from the fruiting bodies of P. pulmonarius var. stechangii by HPLC analysis. The inhibitory effects of ME on α-amylase and α-glucosidase were moderate and lower than that of acarbose, a positive control. The ME inhibited the production of nitric oxide (NO) and nitric oxide synthases (iNOS) protein expression in lipopolysaccharide-induced RAW 264.7 macrophages. It also exhibited an inhibitory effect on carrageenan-induced hind paw edema in a rat model. Taken together, our experimental results demonstrated that the fruiting bodies of P. pulmonarius var. stechangii might be a good natural source to promote human health through its antixanthine oxidase, antihyperglycemia, and anti-inflammatory activities.
- Subjects :
- Animals
Anti-Inflammatory Agents administration & dosage
Anti-Inflammatory Agents chemistry
Edema genetics
Edema metabolism
Female
Glycoside Hydrolase Inhibitors administration & dosage
Glycoside Hydrolase Inhibitors chemistry
Humans
Hypoglycemic Agents administration & dosage
Hypoglycemic Agents chemistry
Macrophages drug effects
Macrophages metabolism
Mice
Nitric Oxide metabolism
Plant Extracts chemistry
RAW 264.7 Cells
Rats
Rats, Sprague-Dawley
alpha-Amylases antagonists & inhibitors
alpha-Amylases chemistry
alpha-Amylases metabolism
alpha-Glucosidases chemistry
alpha-Glucosidases metabolism
Edema drug therapy
Plant Extracts administration & dosage
Pleurotus chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1940-4344
- Volume :
- 22
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- International journal of medicinal mushrooms
- Publication Type :
- Academic Journal
- Accession number :
- 33389870
- Full Text :
- https://doi.org/10.1615/IntJMedMushrooms.2020035566