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Financial Capacity and Regional Cerebral Tau in Cognitively Normal Older Adults, Mild Cognitive Impairment, and Alzheimer's Disease Dementia.
- Source :
-
Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2021; Vol. 79 (3), pp. 1133-1142. - Publication Year :
- 2021
-
Abstract
- Background: Financial capacity is often one of the first instrumental activities of daily living to be affected in cognitively normal (CN) older adults who later progress to amnestic mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia.<br />Objective: The objective of this study was to investigate the association between financial capacity and regional cerebral tau.<br />Methods: Cross-sectional financial capacity was assessed using the Financial Capacity Instrument -Short Form (FCI-SF) in 410 CN, 199 MCI, and 61 AD dementia participants who underwent flortaucipir tau positron emission tomography from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Linear regression models with backward elimination were used with FCI-SF total score as the dependent variable and regional tau and tau-amyloid interaction as predictors of interest in separate analyses. Education, age, sex, Rey Auditory Verbal Learning Test Total Learning, and Trail Making Test B were used as covariates.<br />Results: Significant associations were found between FCI-SF and tau regions (entorhinal: p < 0.001; inferior temporal: p < 0.001; dorsolateral prefrontal: p = 0.01; posterior cingulate: p = 0.03; precuneus: p < 0.001; and supramarginal gyrus: p = 0.005) across all participants. For the tau-amyloid interaction, significant associations were found in four regions (amyloid and dorsolateral prefrontal tau interaction: p = 0.005; amyloid and posterior cingulate tau interaction: p = 0.005; amyloid and precuneus tau interaction: p < 0.001; and amyloid and supramarginal tau interaction: p = 0.002).<br />Conclusion: Greater regional tau burden was modestly associated with financial capacity impairment in early-stage AD. Extending this work with longitudinal analyses will further illustrate the utility of such assessments in detecting clinically meaningful decline, which may aid clinical trials of early-stage AD.
- Subjects :
- Activities of Daily Living psychology
Aged
Aged, 80 and over
Alzheimer Disease diagnosis
Alzheimer Disease pathology
Brain diagnostic imaging
Case-Control Studies
Cognitive Dysfunction diagnosis
Cognitive Dysfunction pathology
Cross-Sectional Studies
Female
Financial Management
Humans
Linear Models
Male
Middle Aged
Positron-Emission Tomography
Severity of Illness Index
Alzheimer Disease psychology
Brain pathology
Cognitive Dysfunction psychology
Mental Competency psychology
tau Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1875-8908
- Volume :
- 79
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of Alzheimer's disease : JAD
- Publication Type :
- Academic Journal
- Accession number :
- 33386806
- Full Text :
- https://doi.org/10.3233/JAD-201122