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PSB 603 - a known selective adenosine A2B receptor antagonist - has anti-inflammatory activity in mice.
- Source :
-
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Mar; Vol. 135, pp. 111164. Date of Electronic Publication: 2020 Dec 29. - Publication Year :
- 2021
-
Abstract
- A <subscript>2B</subscript> adenosine receptors are present in a wide spectrum of tissues, especially on cells of the immune system. Since these particular receptors have the lowest, of all adenosine receptor subtypes, affinity for adenosine they are believed to play a special role in immunological processes associated with elevated adenosine levels such as inflammation. The aim of this preliminary study was to determine the potential anti-inflammatory properties of compound PSB-603, a potent and selective adenosine A <subscript>2B</subscript> receptor antagonist, in two different experimental models of local and systemic inflammation. In a model of inflammation induced by local carrageenan administration paw edema was measured using a pletysmometer. Additionally, levels of C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α) and reactive oxygen species (ROS) were determined in the inflamed paw. Using the mouse model of peripheral inflammation induced by intraperitoneal (ip) administration of zymosan A, the influence of the A <subscript>2B</subscript> antagonist on the infiltration of neutrophils into the peritoneum and its effect on the plasma levels of CRP, TNF-α, and IL-6 were investigated. The results showed that PSB-603 administered at a dose of 5 mg/kg b.w. ip significantly reduced inflammation in both tested models. Particularly, it significantly decreased levels of the inflammatory cytokines IL-6, TNF-α and of ROS in the inflamed paw and reduced inflammation of the peritoneum by significantly decreasing the infiltration of leukocytes. Additionally, in the latter model, no statistically significant difference was observed in the CRP level between the control group without inflammation and the group which has been treated with the PSB-603 compound. Thus, the results may indicate the anti-inflammatory activity of adenosine A <subscript>2B</subscript> receptor antagonists in two different models of inflammation.<br /> (Copyright © 2020 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)
- Subjects :
- Animals
Carrageenan
Disease Models, Animal
Inflammation chemically induced
Inflammation metabolism
Male
Mice
Reactive Oxygen Species metabolism
Receptor, Adenosine A2B metabolism
Signal Transduction
Zymosan
Adenosine A2 Receptor Antagonists pharmacology
Anti-Inflammatory Agents pharmacology
Cytokines metabolism
Inflammation prevention & control
Inflammation Mediators metabolism
Receptor, Adenosine A2B drug effects
Sulfonamides pharmacology
Xanthines pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1950-6007
- Volume :
- 135
- Database :
- MEDLINE
- Journal :
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- Publication Type :
- Academic Journal
- Accession number :
- 33385856
- Full Text :
- https://doi.org/10.1016/j.biopha.2020.111164