Polyoxygenated seco -cyclohexenes derivatives from flower and leaf extracts of Desmos cochinchinensis and their α -glucosidase inhibitory activity.

Authors :: Suthiphasilp V
Maneerat T
Duangyod T
Charoensup R
Andersen RJ
Pyne SG
Laphookhieo S
Source :: Heliyon [Heliyon] 2020 Dec 23; Vol. 6 (12), pp. e05791. Date of Electronic Publication: 2020 Dec 23 (Print Publication: 2020).
Publication Year :: 2020
Abstract: Phytochemical investigations from the flower and leaf extracts of D. cochinchinensis resulted in the isolation and structural elucidation of five new polyoxygenated seco -cyclohexene derivatives, desmoscochinchinenes A-E ( 1 - 5 ), together with 11 known compounds ( 6 - 16 ). The structures on the new compounds were elucidated from their spectroscopic data, including UV, IR, NMR, and HRESITOFMS. Some of the isolated compounds were evaluated for their α -glucosidase inhibitory activities. Chrysin ( 9 ), pinocembrin 7- O -benzoate ( 12 ), and (-)-(5 R )-desmoscochinoxepinone B ( 16 ) inhibited α -glucosidase better than the standard control (acarbose, IC <subscript>50</subscript> = 83.5 μM) with IC <subscript>50</subscript> values of 5.7, 33.8, 53.3 μM, respectively.<br />Competing Interests: The authors declare no conflict of interest.<br /> (© 2020 The Author(s).)

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