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Potential of an Interorgan Network Mediated by Toxic Advanced Glycation End-Products in a Rat Model.
- Source :
-
Nutrients [Nutrients] 2020 Dec 29; Vol. 13 (1). Date of Electronic Publication: 2020 Dec 29. - Publication Year :
- 2020
-
Abstract
- Excessive intake of glucose and fructose in beverages and foods containing high-fructose corn syrup (HFCS) plays a significant role in the progression of lifestyle-related diseases (LSRD). Glyceraldehyde-derived advanced glycation end-products (AGEs), which have been designated as toxic AGEs (TAGE), are involved in LSRD progression. Understanding of the mechanisms underlying the effects of TAGE on gene expression in the kidneys remains limited. In this study, DNA microarray analysis and quantitative real-time polymerase chain reaction (PCR) were used to investigate whether HFCS-consuming Wister rats generated increased intracellular serum TAGE levels, as well as the potential role of TAGE in liver and kidney dysfunction. HFCS consumption resulted in significant accumulation of TAGE in the serum and liver of rats, and induced changes in gene expression in the kidneys without TAGE accumulation or upregulation of receptor for AGEs (RAGE) upregulation. Changes in specific gene expression profiles in the kidney were more correlated with TAGE levels in the liver tissue than in the serum. These findings suggest a direct or indirect interaction may be present between the liver and kidneys that does not involve serum TAGE or RAGE. The involvement of internal signal transduction factors such as exosomes or cytokines without IL-1β and TNF-α is suggested to contribute to the observed changes in kidney gene expression.
- Subjects :
- Animals
Beverages
Calbindin 1
Cytokines blood
Food
Fructose metabolism
Gene Expression
Glycated Hemoglobin
Glycation End Products, Advanced genetics
Humans
Kidney pathology
Liver pathology
Male
Muscle Proteins
Rats
Rats, Wistar
Renal Insufficiency
Transcriptome
Ubiquitin Thiolesterase
Glycation End Products, Advanced blood
Glycation End Products, Advanced toxicity
High Fructose Corn Syrup metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2072-6643
- Volume :
- 13
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nutrients
- Publication Type :
- Academic Journal
- Accession number :
- 33383715
- Full Text :
- https://doi.org/10.3390/nu13010080