Back to Search
Start Over
Polylactose Exhibits Prebiotic Activity and Reduces Adiposity and Nonalcoholic Fatty Liver Disease in Rats Fed a High-Fat Diet.
- Source :
-
The Journal of nutrition [J Nutr] 2021 Feb 01; Vol. 151 (2), pp. 352-360. - Publication Year :
- 2021
-
Abstract
- Background: Prebiotic dietary fibers change the intestinal microbiome favorably and provide a health benefit to the host.<br />Objectives: Polylactose is a novel fiber, synthesized by extrusion of lactose. We evaluated its prebiotic activity by determining its fermentability, effect on the microbiota, and effects on adiposity and liver lipids in a diet-induced obesity animal model.<br />Methods: Male Wistar rats (4-5 wk old) were fed normal-fat (NF, 25% fat energy) or high-fat (HF, 51% fat energy) diets containing different fibers (6% fiber of interest and 3% cellulose, by weight), including cellulose (NFC and HFC, negative and positive controls, respectively), polylactose (HFPL), lactose matched to residual lactose in the HFPL diet, and 2 established prebiotic fibers: polydextrose (HFPD) and fructooligosaccharide (HFFOS). After 10 wk of feeding, organs were harvested and cecal contents collected.<br />Results: HFPL animals had greater cecum weight (3 times greater than HFC) and lower cecal pH (∼1 pH unit lower than HFC) than all other groups, suggesting that polylactose is more fermentable than other prebiotic fibers (HFPD, HFFOS; P < 0.05). HFPL animals also had increased taxonomic abundance of the probiotic species Bifidobacterium in the cecum relative to all other groups (P < 0.05). Epididymal fat pad weight was significantly decreased in the HFPL group (29% decrease compared with HFC) compared with all other HF groups (P < 0.05) and did not differ from the NFC group. Liver lipids and cholesterol were reduced in HFPL animals when compared with HFC animals (P < 0.05).<br />Conclusions: Polylactose is a fermentable fiber that elicits a beneficial change in the gut microbiota as well as reducing adiposity in rats fed HF diets. These effects of polylactose were greater than those of 2 established prebiotics, fructooligosaccharide and polydextrose, suggesting that polylactose is a potent prebiotic.<br /> (© The Author(s) 2020. Published by Oxford University Press on behalf of the American Society for Nutrition.)
- Subjects :
- Adipokines blood
Animals
Bile Acids and Salts
Blood Glucose
Dietary Fiber analysis
Fatty Acids, Volatile
Fermentation
Gastrointestinal Contents chemistry
Gastrointestinal Contents microbiology
Gastrointestinal Microbiome drug effects
Gluconeogenesis
Lactose chemistry
Lactose pharmacology
Lipids blood
Liver chemistry
Liver metabolism
Male
Non-alcoholic Fatty Liver Disease prevention & control
Rats
Rats, Wistar
Adiposity drug effects
Diet, High-Fat adverse effects
Dietary Fiber pharmacology
Lactose analogs & derivatives
Non-alcoholic Fatty Liver Disease chemically induced
Prebiotics administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1541-6100
- Volume :
- 151
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The Journal of nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 33382431
- Full Text :
- https://doi.org/10.1093/jn/nxaa376