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The prevalence of esophageal cancer after caustic and pesticide ingestion: A nationwide cohort study.
- Source :
-
PloS one [PLoS One] 2020 Dec 29; Vol. 15 (12), pp. e0243922. Date of Electronic Publication: 2020 Dec 29 (Print Publication: 2020). - Publication Year :
- 2020
-
Abstract
- Habits such as smoking and alcohol drinking and existing esophageal malfunction are considered the main risk factors for esophageal carcinogenesis. Caustic ingestion of acidic or alkaline agents or strong irritants can induce severe esophageal corrosive injury and increase esophageal cancer risk. We studied the relationship between esophageal carcinoma and acute detergent or pesticide poisoning by using nationwide health insurance data. Methodology/Principle findings: We compared a pesticide/detergent intoxication cohort (N = 21,840) and an age- and gender-matched control cohort (N = 21,840) identified from the National Health Insurance Research Database between 2000 and 2011. We used the multivariable Cox proportional model to determine esophageal carcinoma risk. The overall incidence density of esophageal cancer was 1.66 per 10,000 person-years in the comparison cohort and 4.36 per 10,000 person-years in the pesticide/detergent intoxication cohort. The corresponding adjusted hazard ratio (HR) for esophageal cancer was 2.33 (95% confidence interval [CI] = 1.41-3.86) in the pesticide/detergent intoxication cohort compared with the control cohort. Patients with corrosive and detergent intoxication did not have a higher risk of esophageal cancer (adjusted HR = 0.98, 95% CI = 0.29-3.33) than those without pesticide/detergent intoxication. However, patients with pesticide intoxication had a significantly higher risk of esophageal cancer (adjusted HR = 2.52, 95% CI = 1.52-4.18) than those without pesticide/detergent intoxication. Conclusion: In the present study, after adjusting for conventional risk factors, we observed that pesticide intoxication could exert substantial effects through increased esophageal cancer risk. However, patients with detergent intoxication may not have an increased risk of esophageal cancer.<br />Competing Interests: The authors have declared that no competing interests exist.
- Subjects :
- Adult
Aged
Carcinoma chemically induced
Carcinoma pathology
Cohort Studies
Detergents poisoning
Eating drug effects
Esophageal Neoplasms chemically induced
Esophageal Neoplasms pathology
Female
Humans
Male
Middle Aged
Proportional Hazards Models
Risk Factors
Carcinoma epidemiology
Caustics poisoning
Esophageal Neoplasms epidemiology
Pesticides poisoning
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 15
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 33373373
- Full Text :
- https://doi.org/10.1371/journal.pone.0243922