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Over 12 Years Single Institutional Experience Performing Percutaneous Hepatic Perfusion for Unresectable Liver Metastases.
- Source :
-
Cancer control : journal of the Moffitt Cancer Center [Cancer Control] 2020 Jan-Dec; Vol. 27 (1), pp. 1073274820983019. - Publication Year :
- 2020
-
Abstract
- Patients with unresectable hepatic metastases, from uveal or ocular melanoma, are challenging to treat with an overall poor prognosis. Although over the past decade significant advances in systemic therapies have been made, metastatic disease to the liver, especially from uveal melanoma, continues to be a poor prognosis. Percutaneous hepatic perfusion (PHP) is a safe, viable treatment option for these patients. PHP utilizes high dose chemotherapy delivered directly to the liver while minimizing systemic exposure and can be repeated up to 6 times. Isolation of the hepatic vasculature with a double-balloon catheter allows for high concentration cytotoxic therapy to be administered with minimal systemic adverse effects. A detailed description of the multidisciplinary treatment protocol used at an institution with over 12 years of experience is discussed and recommendations are given. A dedicated team of a surgical or medical oncology, interventional radiology, anesthesiology and a perfusionist allows PHP to be repeatedly performed as a safe treatment strategy for unresectable hepatic metastases.
- Subjects :
- Aged
Antineoplastic Agents, Alkylating adverse effects
Chemotherapy, Cancer, Regional Perfusion adverse effects
Female
Humans
Liver blood supply
Liver diagnostic imaging
Liver drug effects
Liver pathology
Liver Neoplasms mortality
Liver Neoplasms secondary
Male
Medical Oncology organization & administration
Melanoma drug therapy
Melanoma mortality
Melphalan administration & dosage
Melphalan adverse effects
Middle Aged
Patient Care Team organization & administration
Phlebography
Progression-Free Survival
Radiology, Interventional organization & administration
Skin Neoplasms drug therapy
Skin Neoplasms mortality
Uveal Neoplasms drug therapy
Uveal Neoplasms mortality
Antineoplastic Agents, Alkylating administration & dosage
Chemotherapy, Cancer, Regional Perfusion methods
Liver Neoplasms drug therapy
Melanoma pathology
Skin Neoplasms pathology
Uveal Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1526-2359
- Volume :
- 27
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cancer control : journal of the Moffitt Cancer Center
- Publication Type :
- Academic Journal
- Accession number :
- 33372814
- Full Text :
- https://doi.org/10.1177/1073274820983019