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Longitudinal transcriptome analyses show robust T cell immunity during recovery from COVID-19.
- Source :
-
Signal transduction and targeted therapy [Signal Transduct Target Ther] 2020 Dec 24; Vol. 5 (1), pp. 294. Date of Electronic Publication: 2020 Dec 24. - Publication Year :
- 2020
-
Abstract
- Understanding the processes of immune regulation in patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for improving treatment. Here, we performed longitudinal whole-transcriptome RNA sequencing on peripheral blood mononuclear cell (PBMC) samples from 18 patients with coronavirus disease 2019 (COVID-19) during their treatment, convalescence, and rehabilitation. After analyzing the regulatory networks of differentially expressed messenger RNAs (mRNAs), microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) between the different clinical stages, we found that humoral immunity and type I interferon response were significantly downregulated, while robust T-cell activation and differentiation at the whole transcriptome level constituted the main events that occurred during recovery from COVID-19. The formation of this T cell immune response might be driven by the activation of activating protein-1 (AP-1) related signaling pathway and was weakly affected by other clinical features. These findings uncovered the dynamic pattern of immune responses and indicated the key role of T cell immunity in the creation of immune protection against this disease.
- Subjects :
- COVID-19 epidemiology
COVID-19 pathology
Female
Humans
Immunity, Humoral immunology
Leukocytes, Mononuclear metabolism
Male
MicroRNAs
RNA, Long Noncoding genetics
RNA-Seq
SARS-CoV-2 genetics
SARS-CoV-2 pathogenicity
T-Lymphocytes immunology
T-Lymphocytes pathology
Transcription Factor AP-1 genetics
COVID-19 genetics
Immunity, Humoral genetics
T-Lymphocytes metabolism
Transcriptome genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2059-3635
- Volume :
- 5
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Signal transduction and targeted therapy
- Publication Type :
- Academic Journal
- Accession number :
- 33361761
- Full Text :
- https://doi.org/10.1038/s41392-020-00457-4