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Nicardipine: When high dose nitrates fail in treating heart failure.
- Source :
-
The American journal of emergency medicine [Am J Emerg Med] 2021 Jul; Vol. 45, pp. 681.e3-681.e5. Date of Electronic Publication: 2020 Dec 13. - Publication Year :
- 2021
-
Abstract
- Sympathetic Crashing Acute Pulmonary Edema (SCAPE) describes patients who present with acute hypertensive cardiogenic pulmonary edema. These patients present in respiratory distress, and requiring immediate medical and airway management. The treatment of SCAPE includes non-invasive positive pressure ventilation (NIPPV) to maintain oxygenation, and high dose nitrates to lower blood pressure and reduce afterload. We present a case report of a patient with refractory hypertension to high dose nitrates likely due to nitroglycerin resistance or an attenuated response. The addition of nicardipine led to marked clinical improvement, normalized blood pressure and spared the patient from endotracheal intubation and admission to the intensive care unit.<br />Competing Interests: Declaration of Competing Interest None.<br /> (Copyright © 2020. Published by Elsevier Inc.)
- Subjects :
- Administration, Intravenous
Blood Pressure drug effects
Female
Humans
Hypertension etiology
Middle Aged
Nitroglycerin administration & dosage
Nitroglycerin adverse effects
Pulmonary Edema complications
Pulmonary Edema drug therapy
Vasodilator Agents administration & dosage
Vasodilator Agents adverse effects
Calcium Channel Blockers administration & dosage
Hypertension drug therapy
Nicardipine administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1532-8171
- Volume :
- 45
- Database :
- MEDLINE
- Journal :
- The American journal of emergency medicine
- Publication Type :
- Report
- Accession number :
- 33358327
- Full Text :
- https://doi.org/10.1016/j.ajem.2020.12.016