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Sargassum fusiforme polysaccharide partly replaces acarbose against type 2 diabetes in rats.
- Source :
-
International journal of biological macromolecules [Int J Biol Macromol] 2021 Feb 15; Vol. 170, pp. 447-458. Date of Electronic Publication: 2020 Dec 19. - Publication Year :
- 2021
-
Abstract
- The objective of present research was to explore whether Sargassum fusiforme polysaccharide (SFP) could partly replace acarbose against type 2 diabetes in rats. Results indicated that SFP co-administered with low-dose acarbose intervention typically mitigated diabetic symptoms and serum profiles and exhibited better anti-diabetic effects than single acarbose treatment in controlling fasting blood glucose, improving insulin resistance and mitigating kidney injuries. The RT-qPCR analysis indicated that SFP co-administered with low-dose acarbose administration distinctly activated the IRS/PI3K/AKT signaling pathway compared with single acarbose treatment. Moreover, the co-administration also restrained liver fat accumulation via affecting the expression of HMGCR and SREBP-1c genes. In addition, the 16S rRNA gene sequencing analysis indicated that SFP co-administered with low-dose acarbose significantly restored beneficial composition of gut flora in diabetic rats, such as the increase of Muribaculaceae, Lachnospiraceae, Bifidobacterium, Ruminococcaceae&#95;UCG-014, Ruminococcus&#95;1, Romboutsia, Eggerthellaceae, Alistipes and Faecalibaculum, and the decrease of Escherichia-Shigella. These results suggested that SFP, the novel natural adjuvant of acarbose, displayed the desirable benefits in minimizing the dose of drug, while improving the anti-diabetic efficiency.<br />Competing Interests: Declaration of competing interest On behalf of all authors, the corresponding author states that there is no conflict of interest.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Diabetes Mellitus, Experimental metabolism
Diabetes Mellitus, Experimental microbiology
Diabetes Mellitus, Type 2 metabolism
Diabetes Mellitus, Type 2 microbiology
Disease Models, Animal
Fats metabolism
Gastrointestinal Microbiome drug effects
Hypoglycemic Agents pharmacology
Liver drug effects
RNA, Ribosomal, 16S metabolism
Rats
Rats, Sprague-Dawley
Signal Transduction drug effects
Acarbose pharmacology
Diabetes Mellitus, Experimental drug therapy
Diabetes Mellitus, Type 2 drug therapy
Polysaccharides pharmacology
Sargassum metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0003
- Volume :
- 170
- Database :
- MEDLINE
- Journal :
- International journal of biological macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 33352159
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2020.12.126