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Catalytic polymersomes to produce strong and long-lasting bioluminescence.

Catalytic polymersomes to produce strong and long-lasting bioluminescence.

Authors :
Meyer CE
Craciun I
Schoenenberger CA
Wehr R
Palivan CG
Source :
Nanoscale [Nanoscale] 2021 Jan 07; Vol. 13 (1), pp. 66-70. Date of Electronic Publication: 2020 Dec 22.
Publication Year :
2021

Abstract

Here, we introduce an artificial bioluminescent nanocompartment based on the encapsulation of light-producing enzymes, luciferases, inside polymersomes. We exploit nanocompartmentalization to enhance luciferase stability in a cellular environment but also to positively modulate enzyme kinetics to achieve a long-lasting glow type signal. These features pave the way for expanding bioluminescence to nanotechnology-based applications.

Details

Language :
English
ISSN :
2040-3372
Volume :
13
Issue :
1
Database :
MEDLINE
Journal :
Nanoscale
Publication Type :
Academic Journal
Accession number :
33350424
Full Text :
https://doi.org/10.1039/d0nr07178a