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Lipid Transfer Protein Sensitization: Risk of Anaphylaxis and Molecular Sensitization Profile in Pru p 3-Sensitized Patients.
- Source :
-
International archives of allergy and immunology [Int Arch Allergy Immunol] 2021; Vol. 182 (5), pp. 425-432. Date of Electronic Publication: 2020 Dec 18. - Publication Year :
- 2021
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Abstract
- Background: Component-resolved diagnosis reveals the IgE response to many inhaled, food, and other allergens, improving the understanding and diagnosis of allergic diseases.<br />Objective: The aims of the study are to study the recognition of different lipid transfer proteins (LTPs) and other allergen families in a large group of people sensitized to Pru p 3 and to analyze the relationship between the clinical entities and the allergens.<br />Methods: This cross-sectional study included a large cohort of patients with positive skin tests to peach fruit and Pru p 3 specific IgE antibodies. Respiratory and food allergy symptoms were collected, and we performed prick tests with pollen, plant food, and other allergens plus the ImmunoCAP ISAC assay.<br />Results: Our sample consisted of 421 people with a mean age of 33.25 years (range 16-68); 54.6% were women. Clinical entities included anaphylaxis (37.1%), urticaria (67.9%), and oral allergy syndrome (59.1%). Rhinitis, rhinoconjunctivitis, and/or asthma were diagnosed in 71.8% of the participants. The most pronounced correlation existed between sensitization to Pru p 3 and to Jug r 3, Pla a 3, Ara h 9, and Cor a 8. We found a higher incidence of anaphylaxis in people with 5 or more recognized LTPs. No association was observed between inhaled and food allergies.<br />Conclusion: Most Pru p 3-sensitized participants were sensitized to additional allergens from the same family and, to a lesser extent, to other allergens, mainly in the profilin and PR-10 protein families. Anaphylaxis occurred in more than a third of the cases evaluated, and almost three-quarters of them had respiratory symptoms. Respiratory and food allergies involving LTPs do not seem to be associated.<br /> (© 2020 S. Karger AG, Basel.)
- Subjects :
- Adolescent
Adult
Aged
Anaphylaxis diagnosis
Cross-Sectional Studies
Diagnosis, Differential
Female
Humans
Immunoglobulin E blood
Immunoglobulin E immunology
Incidence
Male
Middle Aged
Risk Assessment
Risk Factors
Young Adult
Anaphylaxis epidemiology
Anaphylaxis etiology
Antigens, Plant immunology
Carrier Proteins immunology
Plant Proteins immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1423-0097
- Volume :
- 182
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- International archives of allergy and immunology
- Publication Type :
- Academic Journal
- Accession number :
- 33341818
- Full Text :
- https://doi.org/10.1159/000511977