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The Impact of [C16Pyr][Amp] on the Aggressiveness in Breast and Prostate Cancer Cell Lines.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2020 Dec 16; Vol. 21 (24). Date of Electronic Publication: 2020 Dec 16. - Publication Year :
- 2020
-
Abstract
- Breast (BrCa) and prostate (PCa) cancers are the most common malignancies in women and men, respectively. The available therapeutic options for these tumors are still not curative and have severe side effects. Therefore, there is an urgent need for more effective antineoplastic agents. Herein, BrCa, PCa, and benign cell lines were treated with two ionic liquids and two quinoxalines and functional experiments were performed-namely cell viability, apoptosis, cytotoxicity, and colony formation assays. At the molecular level, an array of gene expressions encompassing several molecular pathways were used to explore the impact of treatment on gene expression. Although both quinoxalines and the ionic liquid [C2OHMIM][Amp] did not show any effect on the BrCa and PCa cell lines, [C16Pyr][Amp] significantly decreased cell viability and colony formation ability, while it increased the apoptosis levels of all cell lines. Importantly, [C16Pyr][Amp] was found to be more selective for cancer cells and less toxic than cisplatin. At the molecular level, this ionic liquid was also associated with reduced expression levels of CPT2 , LDHA , MCM2, and SKP2 , in both BrCa and PCa cell lines. Hence, [C16Pyr][Amp] was shown to be a promising anticancer therapeutic agent for BrCa and PCa cell lines.
- Subjects :
- Ampicillin chemistry
Antineoplastic Agents chemistry
Cell Line, Tumor
Female
Humans
Ionic Liquids chemistry
Male
Pyridinium Compounds chemistry
Quinoxalines chemistry
Antineoplastic Agents pharmacology
Apoptosis drug effects
Breast Neoplasms metabolism
Ionic Liquids pharmacology
Prostatic Neoplasms metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 21
- Issue :
- 24
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 33339207
- Full Text :
- https://doi.org/10.3390/ijms21249584