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Time-restricted feeding alters isoflurane-induced memory deficits.

Authors :: Song J
Chu S
Fang X
Xu F
Zhang P
Zhao X
Ma Z
Xia T
Gu X
Source :: Translational neuroscience [Transl Neurosci] 2020 Sep 21; Vol. 11 (1), pp. 341-355. Date of Electronic Publication: 2020 Sep 21 (Print Publication: 2020).
Publication Year :: 2020
Abstract: Food consumption during the rest phase promotes circadian desynchrony, which is corrected with harmful physiological and mental disorders. Previously, we found that circadian desynchrony was involved in isoflurane-induced cognitive impairment. Here, we scheduled food access to modulate daily rhythm to examine its impact on isoflurane-induced cognitive impairments. Mice were randomly transferred to restricted feeding (RF) time groups: Control group (Zeitgeber time (ZT) 0-ZT24, ad libitum feeding), Day-Feeding group (ZT0-ZT12, misaligned feeding), and Night-Feeding group (ZT12-ZT24, aligned feeding). Then, some of them were subjected to 5 h of 1.3% isoflurane anaesthesia from ZT14 to ZT19 and were divided into the Control + Anes group, the Day-Feeding + Anes group, and the Night-Feeding + Anes group. Mini-Mitter was used to monitor the daily rhythm. Fear conditioning system was conducted to assess cognition of mice. We observed that the Night-Feeding group adapted to RF gradually, whereas the Day-Feeding group exhibited a disturbed daily rhythm. The Night-Feeding + Anes group exhibited a partially enhanced daily rhythm, whereas the Day-Feeding + Anes group exhibited sustained phase advances and diurnality score increase 7 days after isoflurane anaesthesia. Notably, in tests of hippocampus-dependent contextual memory, the Night-Feeding + Anes group demonstrated decreased deficits; the Day-Feeding + Anes group showed prolonged post-anaesthetic deficits 14 days after isoflurane anaesthesia. However, amygdala-dependent cued-fear conditioning post-anaesthesia was not altered by the RF schedule. In conclusion, we demonstrated that misaligned feeding disturbed the daily rhythm and led to persistent post-anaesthetic cognitive dysfunction. Aligned feeding enhanced the daily rhythm partially and improved post-anaesthetic cognitive dysfunction.<br />Competing Interests: Conflict of interest: The authors state no conflict of interest.<br /> (© 2020 Jia Song et al., published by De Gruyter.)