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Is microvascular dysfunction a systemic disorder with common biomarkers found in the heart, brain, and kidneys? - A scoping review.
- Source :
-
Microvascular research [Microvasc Res] 2021 Mar; Vol. 134, pp. 104123. Date of Electronic Publication: 2020 Dec 15. - Publication Year :
- 2021
-
Abstract
- Although microvascular dysfunction (MVD) has been well characterized in individual organs as different disease entities, clinical evidence is mounting in support of an underlying systemic process. To address this hypothesis, we systematically searched PubMed and Medline for studies in adults published between 2014 and 2019 that measured blood biomarkers of MVD in three vital organs i.e. brain, heart, and the kidney. Of the 9706 unique articles 321 met the criteria, reporting 49 biomarkers of which 16 were common to the three organs. Endothelial dysfunction, inflammation including reactive oxidation, immune activation, and coagulation were the commonly recognized pathways. Triglyceride, C-reactive protein, Cystatin C, homocysteine, uric acid, IL-6, NT-proBNP, thrombomodulin, von Willebrand Factor, and uric acid were increased in MVD of all three organs. In contrast, vitamin D was decreased. Adiponectin, asymmetric dimethylarginine, total cholesterol, high-density and low-density cholesterol were found to be variably increased or decreased in studies. We review the pathways underlying MVD in the three organs and summarize evidence supporting its systemic nature. This scoping review informs clinicians and researchers in the multi-system manifestation of MVD. Future work should focus on longitudinal investigations to evaluate the multi-system involvement of this disease.<br /> (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Subjects :
- Biomarkers metabolism
Cerebral Small Vessel Diseases physiopathology
Cerebrovascular Circulation
Coronary Artery Disease physiopathology
Coronary Circulation
Coronary Vessels physiopathology
Female
Humans
Male
Microcirculation
Microvessels physiopathology
Middle Aged
Renal Circulation
Renal Insufficiency, Chronic physiopathology
Brain blood supply
Cerebral Small Vessel Diseases metabolism
Coronary Artery Disease metabolism
Coronary Vessels metabolism
Kidney blood supply
Microvessels metabolism
Renal Insufficiency, Chronic metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9319
- Volume :
- 134
- Database :
- MEDLINE
- Journal :
- Microvascular research
- Publication Type :
- Academic Journal
- Accession number :
- 33333140
- Full Text :
- https://doi.org/10.1016/j.mvr.2020.104123