Case Report: Convalescent Plasma, a Targeted Therapy for Patients with CVID and Severe COVID-19.

The disease course of COVID-19 in patients with immunodeficiencies is unclear, as well as the optimal therapeutic strategy. We report a case of a 37-year old male with common variable immunodeficiency disorder and a severe SARS-CoV-2 infection. After administration of convalescent plasma, the patient's condition improved rapidly. Despite clinical recovery, viral RNA remained detectable up to 60 days after onset of symptoms. We propose that convalescent plasma might be considered as a treatment option in patients with CVID and severe COVID-19. In addition, in patients with immunodeficiencies, a different clinical course is possible, with prolonged viral shedding.
Competing Interests: AS is a consultant for Gritstone, Flow Pharma, Avalia. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2020 Van Damme, Tavernier, Van Roy, De Leeuw, Declercq, Bosteels, Maes, De Bruyne, Bogaert, Bosteels, Hoste, Naesens, Maes, Grifoni, Weiskopf, Sette, Depuydt, Van Braeckel, Haerynck and Lambrecht.)