AnnoLnc: A One-Stop Portal to Systematically Annotate Novel Human Long Noncoding RNAs.

While more than a hundred thousand long noncoding RNAs (lncRNAs) have been identified in human genome, their biological functions and regulation are largely elusive. Here we present AnnoLnc, a one-stop online annotation portal for human lncRNAs ( http://annolnc1.gao-lab.org/ ). As the first (and the most comprehensive) Web server to provide on-the-fly annotation for novel human lncRNAs, AnnoLnc exploits more than 700 data sources to annotate inputted lncRNA systematically, spanning genomic location, secondary structure, expression patterns, coexpression-based functional annotation, transcriptional regulation, miRNA interaction, protein interaction, genetic association, and evolution. Moreover, in addition to a user-friendly Web interface, AnnoLnc can also be integrated into existing pipelines by either a set of JSON-based web service APIs or a stand-alone version for Linux server.