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Reduced Pulsatile Trabecular Meshwork Motion in Eyes With Primary Open Angle Glaucoma Using Phase-Sensitive Optical Coherence Tomography.
- Source :
-
Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2020 Dec 01; Vol. 61 (14), pp. 21. - Publication Year :
- 2020
-
Abstract
- Purpose: The purpose of this study was to investigate the difference in pulsatile trabecular meshwork (TM) motion between normal and eyes with POAG using phase-sensitive optical coherence tomography (PhS-OCT).<br />Methods: In this cross-sectional study, eight healthy subjects (16 eyes) and nine patients with POAG (18 eyes) were enrolled. A laboratory-based prototype PhS-OCT system was used to measure pulsatile TM motion. PhS-OCT images were analyzed to obtain parameters of pulsatile TM motion (i.e. maximum velocity [MV] and cumulative displacement [CDisp]). Outflow facility and ocular pulse amplitude were measured using pneumotonography. Detection sensitivity was compared among various parameters by calculating the area under the receiver operating characteristic curves (AUCs).<br />Results: A pulsatile TM motion waveform synchronous with digital pulse was observed using PhS-OCT in both healthy and POAG eyes. The mean MV in eyes with glaucoma was significantly lower than healthy eyes (P < 0.001). The mean CDisp in POAG eyes was also significantly lower than healthy eyes (P < 0.001). CDisp showed a significant correlation (r = 0.46; P = 0.0088) with ocular pulse amplitude in the study. Compared with the outflow facility, both the MV and CDisp were found to have a better discrimination of glaucoma (P < 0.001 and P = 0.0074, respectively).<br />Conclusions: Pulsatile TM motion was reduced in patients with POAG compared to healthy subjects. The underlying mechanism may be due to the altered tissue stiffness or other biomechanical properties of the TM in POAG eyes. Our evidence suggests that the measurement of pulsatile TM motion with PhS-OCT may help in characterizing outflow pathway abnormalities.
- Subjects :
- Aged
Aged, 80 and over
Case-Control Studies
Cross-Sectional Studies
Glaucoma, Open-Angle pathology
Glaucoma, Open-Angle physiopathology
Humans
Middle Aged
Tomography, Optical Coherence
Trabecular Meshwork pathology
Trabecular Meshwork physiopathology
Glaucoma, Open-Angle diagnostic imaging
Trabecular Meshwork diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1552-5783
- Volume :
- 61
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Investigative ophthalmology & visual science
- Publication Type :
- Academic Journal
- Accession number :
- 33326017
- Full Text :
- https://doi.org/10.1167/iovs.61.14.21