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Alveolar Soft Part Sarcoma of Uterine Corpus in a Young Female: A Case Report With Review of Literature.
- Source :
-
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists [Int J Gynecol Pathol] 2021 May 01; Vol. 40 (3), pp. 272-277. - Publication Year :
- 2021
-
Abstract
- Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma, often occurs in adolescents and young adults with a particular predilection for the deep soft tissue of extremities. Occurrence of ASPS in the female genital tract is very uncommon and poses a significant diagnostic challenge. A case of ASPS of the uterine corpus is described in a young unmarried female, who presented to the out-patient clinic of our Institute with complaints of abnormal uterine bleeding for the past 9 mo. She was being treated with oral contraceptive pills, progesterone and tranexamic acid. Following radiological imaging and hysteroscopy, a therapeutic curettage of the lesion was done. The histopathologic features raised a differential diagnosis of a myriad of morphologic mimickers. The diagnosis was clinched by exclusion of mimickers by relevant immunohistochemical markers and strong nuclear expression of TFE3 on immunohistochemistry. The patient is on regular follow-up with oral contraceptives and antifibrinolytic medication. Despite being infrequent at this location, ASPS should be kept in differential diagnosis in young females presenting with abnormal uterine bleeding.<br />Competing Interests: The authors declare no conflict of interest.<br /> (Copyright © 2020 by the International Society of Gynecological Pathologists.)
- Subjects :
- Diagnosis, Differential
Female
Humans
Immunohistochemistry
Sarcoma, Alveolar Soft Part pathology
Sarcoma, Alveolar Soft Part surgery
Soft Tissue Neoplasms pathology
Soft Tissue Neoplasms surgery
Uterine Hemorrhage pathology
Uterus pathology
Young Adult
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors metabolism
Sarcoma, Alveolar Soft Part diagnosis
Soft Tissue Neoplasms diagnosis
Uterine Hemorrhage diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1538-7151
- Volume :
- 40
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists
- Publication Type :
- Academic Journal
- Accession number :
- 33323848
- Full Text :
- https://doi.org/10.1097/PGP.0000000000000700