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Genetic Predisposition to Coronary Artery Disease in Type 2 Diabetes Mellitus.

Authors :: van Zuydam NR
Ladenvall C
Voight BF
Strawbridge RJ
Fernandez-Tajes J
Rayner NW
Robertson NR
Mahajan A
Vlachopoulou E
Goel A
Kleber ME
Nelson CP
Kwee LC
Esko T
Mihailov E
Mägi R
Milani L
Fischer K
Kanoni S
Kumar J
Song C
Hartiala JA
Pedersen NL
Perola M
Gieger C
Peters A
Qu L
Willems SM
Doney ASF
Morris AD
Zheng Y
Sesti G
Hu FB
Qi L
Laakso M
Thorsteinsdottir U
Grallert H
van Duijn C
Reilly MP
Ingelsson E
Deloukas P
Kathiresan S
Metspalu A
Shah SH
Sinisalo J
Salomaa V
Hamsten A
Samani NJ
März W
Hazen SL
Watkins H
Saleheen D
Morris AP
Colhoun HM
Groop L
McCarthy MI
Palmer CNA
Source :: Circulation. Genomic and precision medicine [Circ Genom Precis Med] 2020 Dec; Vol. 13 (6), pp. e002769. Date of Electronic Publication: 2020 Aug 13.
Publication Year :: 2020
Abstract: Background: Coronary artery disease (CAD) is accelerated in subjects with type 2 diabetes mellitus (T2D).<br />Methods: To test whether this reflects differential genetic influences on CAD risk in subjects with T2D, we performed a systematic assessment of genetic overlap between CAD and T2D in 66 643 subjects (27 708 with CAD and 24 259 with T2D). Variants showing apparent association with CAD in stratified analyses or evidence of interaction were evaluated in a further 117 787 subjects (16 694 with CAD and 11 537 with T2D).<br />Results: None of the previously characterized CAD loci was found to have specific effects on CAD in T2D individuals, and a genome-wide interaction analysis found no new variants for CAD that could be considered T2D specific. When we considered the overall genetic correlations between CAD and its risk factors, we found no substantial differences in these relationships by T2D background.<br />Conclusions: This study found no evidence that the genetic architecture of CAD differs in those with T2D compared with those without T2D.