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Effect of sulfur dioxide on vascular biology.
- Source :
-
Histology and histopathology [Histol Histopathol] 2021 May; Vol. 36 (5), pp. 505-514. Date of Electronic Publication: 2020 Dec 15. - Publication Year :
- 2021
-
Abstract
- Gasotransmitters, such as nitric oxide, carbon monoxide and hydrogen sulfide, can be generated endogenously. These gasotransmitters play important roles in vascular biology, including vasorelaxation and inhibition of vascular smooth muscle cell (VSMC) proliferation. In recent years, sulfur dioxide (SO₂) has been considered as a fourth gasotransmitter. SO₂ is present in air pollution. Moreover, SO₂ toxicity, including oxidative stress and DNA damage, has been extensively reported in previous studies. Recent studies have shown that SO₂ can be endogenously generated in various organs and vascular tissues, where it regulates vascular tone, vascular smooth cell proliferation and collagen synthesis. SO₂ can decrease blood pressure in rats, inhibit smooth muscle cell proliferation and collagen accumulation and promote collagen degradation, and improve vascular remodelling. SO₂ can decrease cardiovascular atherosclerotic plaques by enhancing the antioxidant effect and upregulating nitric oxide/nitric oxide synthase and hydrogen sulfide/cystathionine-γ-lyase pathways. SO₂ can also ameliorate vascular calcification via the transforming growth factor - β1/Smad pathway. The effect of SO₂ on vascular regulation has attracted great interest. SO₂ may be a novel mediator in vascular biology.
- Subjects :
- Carbon Monoxide metabolism
Cardiovascular Abnormalities drug therapy
Cell Proliferation drug effects
Hydrogen Sulfide metabolism
Nitric Oxide metabolism
Signal Transduction drug effects
Cardiovascular System drug effects
Gasotransmitters metabolism
Gasotransmitters pharmacology
Sulfur Dioxide metabolism
Sulfur Dioxide pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1699-5848
- Volume :
- 36
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Histology and histopathology
- Publication Type :
- Academic Journal
- Accession number :
- 33319344
- Full Text :
- https://doi.org/10.14670/HH-18-290