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Structurally diverse polyketides and phenylspirodrimanes from the soft coral-associated fungus Stachybotrys chartarum SCSIO41201.
- Source :
-
The Journal of antibiotics [J Antibiot (Tokyo)] 2021 Mar; Vol. 74 (3), pp. 190-198. Date of Electronic Publication: 2020 Dec 14. - Publication Year :
- 2021
-
Abstract
- Four undescribed polyketide derivatives, named arthproliferins A-D (1-4), and one undescribed phenylspirodrimane derivative, named arthproliferin E (7), along with 11 known metabolites (5, 6, 8-16) were isolated from the soft coral-associated fungus Stachybotrys chartarum SCSIO41201. Their structures were determined through spectroscopic methods, X-ray crystallography, and ECD analysis. Compounds 1 and 3-15 were evaluated for their cytotoxic, and antibacterial activities. Among them, compounds 1 and 15 displayed moderate inhibitory activity against methicillin-resistant Staphylococcus aureus ATCC 29213 with an MIC value of 78 and 39 µg/mL, respectively. Furthermore, compound 15 displayed strong cytotoxic activities against the tested cell line with IC <subscript>50</subscript> values less than 39 nM.
- Subjects :
- Anti-Bacterial Agents chemistry
Anti-Bacterial Agents pharmacology
Antineoplastic Agents chemistry
Antineoplastic Agents pharmacology
Cell Line, Tumor
Humans
Inhibitory Concentration 50
Methicillin-Resistant Staphylococcus aureus drug effects
Polyketides chemistry
Polyketides pharmacology
Spiro Compounds chemistry
Spiro Compounds pharmacology
Anti-Bacterial Agents isolation & purification
Antineoplastic Agents isolation & purification
Polyketides isolation & purification
Spiro Compounds isolation & purification
Stachybotrys metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1881-1469
- Volume :
- 74
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of antibiotics
- Publication Type :
- Academic Journal
- Accession number :
- 33318621
- Full Text :
- https://doi.org/10.1038/s41429-020-00386-y