Back to Search
Start Over
Management and outcome of hepatic artery thrombosis after pediatric liver transplantation.
Management and outcome of hepatic artery thrombosis after pediatric liver transplantation.
- Source :
-
Pediatric transplantation [Pediatr Transplant] 2021 Aug; Vol. 25 (5), pp. e13938. Date of Electronic Publication: 2020 Dec 12. - Publication Year :
- 2021
-
Abstract
- Background: Pediatric LT are at particular risk of HAT, and its management still constitutes a matter of debate. Our purpose was to study predisposing factors and outcome of HAT post-LT, including the impact of surgical revisions on survival and biliary complications.<br />Methods: Among 882 primary pediatric LT performed between 1993 and 2015, 36 HAT were encountered (4.1%, 35 fully documented). Each HAT case was retrospectively paired with a LT recipient without HAT, according to diagnosis, age at LT, type of graft, and era.<br />Results: Five-year patient survivals were 77.0% versus 83.9% in HAT and non-HAT paired groups, respectively (P = .321). Corresponding graft survivals were 20.0% versus 80.5% (P < .001), and retransplantation rates 77.7% versus 10.7%, respectively (P < .001). One-year biliary complication-free survivals were 16.6% versus 83.8% in the HAT and non-HAT groups, respectively (P < .001). Regarding chronology of surgical re-exploration, only HAT cases that occurred within 14 days post-LT were re-operated, fourteen of them being explored within 7 days post-LT (revascularization rate: 6/14), versus two beyond 7 days (no revascularization). When revascularization was achieved, graft and biliary complication-free survival rates at 1 year were 33.3% and 22.2%, respectively, both rates being 0.0% in case of failure.<br />Conclusions: The pejorative prognosis associated with HAT in terms of graft survival is confirmed, whereas patient survival could be preserved through retransplantation. Results suggest that HAT should be re-operated if occurring within 7 days post-LT, but not beyond.<br /> (© 2020 Wiley Periodicals LLC.)
- Subjects :
- Adolescent
Child
Child, Preschool
Graft Survival
Humans
Immunosuppression Therapy methods
Infant
Postoperative Complications etiology
Prognosis
Reoperation statistics & numerical data
Risk Factors
Thrombosis etiology
Young Adult
Hepatic Artery
Liver blood supply
Liver Transplantation
Postoperative Complications therapy
Thrombosis therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1399-3046
- Volume :
- 25
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Pediatric transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 33314551
- Full Text :
- https://doi.org/10.1111/petr.13938