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Type 1 diabetes mellitus in patients with recurrent acute and chronic pancreatitis: A case series.
- Source :
-
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] [Pancreatology] 2021 Jan; Vol. 21 (1), pp. 95-97. Date of Electronic Publication: 2020 Dec 06. - Publication Year :
- 2021
-
Abstract
- Background/objectives: Pancreatogenic diabetes mellitus has been assumed to result from non-immune beta cell destruction when the pancreas is replaced by fibrotic tissue secondary to acute and chronic pancreatitis. We hypothesize that recurrent episodes of pancreatic inflammation may increase the risk for developing β-cell autoimmunity in susceptible individuals.<br />Methods: We describe 11 patients who had both recurrent acute and/or chronic pancreatitis and type 1 diabetes (T1D) requiring insulin therapy.<br />Results: All 11 patients had positive autoantibodies and 8 patients tested had minimal to undetectable (7/8) or moderate (1/8) stimulated C-peptide at 12 months after T1D onset. Three had biopsy confirmation of insulitis.<br />Conclusions: These cases lend support to the theory that pancreatitis may increase risk for T1D. We postulate that the pro-inflammatory conditions of pancreatitis may increase posttranslational protein modifications of β-cell antigens and neoepitope generation, which are potential initiating events for loss of β-cell self-tolerance.<br /> (Copyright © 2020 IAP and EPC. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Acute Disease
Adolescent
Adult
Autoantibodies blood
C-Peptide blood
Child
Child, Preschool
Chronic Disease
Diabetes Mellitus, Type 1 blood
Humans
Infant
Inflammation
Middle Aged
Pancreatitis blood
Protein Processing, Post-Translational
Recurrence
Risk Factors
Young Adult
Diabetes Mellitus, Type 1 complications
Pancreatitis complications
Subjects
Details
- Language :
- English
- ISSN :
- 1424-3911
- Volume :
- 21
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
- Publication Type :
- Academic Journal
- Accession number :
- 33309625
- Full Text :
- https://doi.org/10.1016/j.pan.2020.12.006