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Posterior cingulate gyri metabolic alterations in HIV-positive patients with and without memory deficits.
- Source :
-
Radiologia brasileira [Radiol Bras] 2020 Nov-Dec; Vol. 53 (6), pp. 359-365. - Publication Year :
- 2020
-
Abstract
- Objective: We aimed to evaluate whether human immunodeficiency virus (HIV)-positive patients with and without clinically significant memory deficits and healthy control participants differ on in vivo hydrogen-1 magnetic resonance spectroscopy (H-MRS) in the posterior cingulate gyri.<br />Materials and Methods: In total, 21 HIV-positive patients with memory deficit (HIV+wMD) were compared with 15 HIV-positive patients without memory deficit (HIV+wOMD) and 22 sex-, age-, and education-matched control participants. Memory impairments were classified based on the participants' performance on the Rey Auditory Verbal Learning Test. Short echo time (30 ms), single-voxel H-MRS was performed using a 1.5-T magnetic resonance scanner.<br />Results: The HIV+wMD and HIV+wOMD groups had higher choline/creatine ratio in the posterior cingulate gyri than the control group. There were no significant metabolite ratio differences between the HIV+wMD and HIV+wOMD groups.<br />Conclusion: HIV-positive patients with and without memory deficits had significantly higher choline/creatine ratios than controls in the posterior cingulate gyri, which may reflect cerebral inflammation, altered cell membrane metabolism, microgliosis, and/or astrocytosis.
Details
- Language :
- English
- ISSN :
- 0100-3984
- Volume :
- 53
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Radiologia brasileira
- Publication Type :
- Academic Journal
- Accession number :
- 33304002
- Full Text :
- https://doi.org/10.1590/0100-3984.2019.0093